The nature has provided abundant plant wealth for all the living creatures, which
possess medicinal virtues. Therefore, there is a necessity to explore their uses and to
ascertain their therapeutic properties. In that way, the Traditional Siddha Medicine plays a
vital role in preventing the progress of the disease. Saint Yugi (one of the Founders of Traditional Indian
Siddha system of Medicine) describes 21 types of Mega noigal, which includes Madhu megam (Madhu –
Sweet, Megam – Disease) [1, 2]. Diabetes mellitus is compared with Madhu megam in Siddha literature.
Diabetes mellitus is a complex and a diverse group of disorders that disturbs the metabolism of carbohydrate,
fat and protein. The number of diabetes mellitus cases has been increasing worldwide in recent years. Insulin
is a key player in the control of glucose homeostasis. Lack of insulin affects carbohydrate, fat and protein
metabolism. Management of diabetes without side effects is still a great challenge to the medical community
. The aim of the present study is to investigate the in-vitro Anti-Diabetic activity of the selected Herbo-
Mineral drug, having its reference in age old Siddha classic text “Sarabhendhirar Vaithiya Ratnavali”. Thus,
validating the traditional claim of the Herbo-mineral drug exhibits a significant inhibitory effect on In-vitro
glucose diffusion and the result is being discussed.