The preparation and decoration of smart composite nanoparticles have been reported. The
noble metal nanomaterials, quatum dots, silica-based nanostructures and their nanoconjugates possess
physical and chemical properties that strongly deviated from those typical for bulk materials. The
structure of composits consists of a core and is usually coated with a shell. The shell acts as an external
envelop which enhances the colloidal stability of nanoconjugates and photoluminescence properties of
the QDs and renders protection to the core of the nanocrystal from photo-initiated degradation. The
preparation and modification of the smart nanostructures are described. Biodecorated hybrid nanostructures
with different functional ligands used for various bioanalytical applications have been also
reported. The composite nanoparticles coated by organic shells with functional groups were considered to govern the covalent
immobilization of biomolecules. The hybrid nano(bio)materials namely silica- and noble metal- based nanomaterials
have recently been explored and are used for imaging and therapeutic applications. The enhanced cellular drug delivery
to cancer cell lines via nanoconjugates revealed that PEG-covered gold nanoparticles are an effective tool for transporting
and delivering platinum-bassed drugs. Biodecorated nanoparticles provide opportunities for designing various
types of therapeutics with novel properties that are not possible to obtain with traditional therapeutics.
Keywords: Composite and hybrid nanoparticles, biomolecules, biodecoration, application, cancer treatment.
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