Title:Novel Inflammatory Indices in Aortic Disease
VOLUME: 22 ISSUE: 23
Author(s):Manolis Vavuranakis, Maria Kariori, Dimitrios Vrachatis, Gerasimos Siasos, Konstantinos Kalogeras, Evelina Bei, Carmen Moldovan, Maria Lavda, Konstantinos Aznaouridis, Evangelos Oikonomou and Dimitris Tousoulis
Affiliation:1st Department of Cardiology, Hippokration Hospital, Medical School, National & Kapodistrian, University of Athens, Greece.
Keywords:Aortic aneurysm, aortic disease, aortic dissection, aortic stenosis, biomarkers.
Abstract:Inflammation plays a critical role in the atherosclerotic process in various vascular beds,
starting from endothelial dysfunction and counting all stages of plaque development. The significant
contribution of inflammation in the initiation and progression of atherosclerosis has been documented
over many years but its contribution to the development of other cardiovascular disease remains unclear.
Inflammatory process constitutes a basic part of pathogenic cascade of aortic diseases including
those of aortic valve stenosis and aortic aneurysms. Thus, both of these entities are related with high
rates of morbidity and mortality. Therefore, the need to detect and investigate indices representative of
inflammation that will be easily measured and may reflect the process of these diseases, is mandatory. However, such
biomarkers for aortic diseases that could have a significant prognostic value on survival via the early identification of high
risk patients, in general, remain few. Therefore, the illumination of role of such biomarkers, will facilitate the understanding
of the mechanisms in molecular and/or cellular level that are responsible for the creation of aortic disease. Such an approach
may provide a pathophysiological basis for early diagnosis.
