Abstract
Cervical cancer is the second leading gynecological malignancy threat to the health of women in the world. However, few improvements in the efficacy of treatments of cervical cancer have been reported for the recurrent and metastasis patterns. As an endogenous antitumor agent, pigment epithelium derived factor (PEDF) has attracted wide attention, and its sensitivity to estrogen suggests a special role in female tumors, including cervical cancer. This review aims to summarize recent findings, the role of PEDF in cervical cancer treatment, and enhance the current understanding of the antitumor properties of PEDF such as inhibiting angiogenesis and metastasis, inducing tumor cell apoptosis and differentiation, and modulating cellular immunity against cervical cancer. The production and delivery of PEDF, as well as derived short peptides and their respective receptors will also be discussed.
Keywords: Cervical cancer, pigment epithelium derived factor, angiogenesis, differentiation, apoptosis, immune, metastasis.
Current Molecular Medicine
Title:Current Evidence and Potential Mechanisms of Therapeutic Action of PEDF in Cervical Cancer Treatment
Volume: 15 Issue: 5
Author(s): J. Han and J. Guo
Affiliation:
Keywords: Cervical cancer, pigment epithelium derived factor, angiogenesis, differentiation, apoptosis, immune, metastasis.
Abstract: Cervical cancer is the second leading gynecological malignancy threat to the health of women in the world. However, few improvements in the efficacy of treatments of cervical cancer have been reported for the recurrent and metastasis patterns. As an endogenous antitumor agent, pigment epithelium derived factor (PEDF) has attracted wide attention, and its sensitivity to estrogen suggests a special role in female tumors, including cervical cancer. This review aims to summarize recent findings, the role of PEDF in cervical cancer treatment, and enhance the current understanding of the antitumor properties of PEDF such as inhibiting angiogenesis and metastasis, inducing tumor cell apoptosis and differentiation, and modulating cellular immunity against cervical cancer. The production and delivery of PEDF, as well as derived short peptides and their respective receptors will also be discussed.
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Cite this article as:
Han J. and Guo J., Current Evidence and Potential Mechanisms of Therapeutic Action of PEDF in Cervical Cancer Treatment, Current Molecular Medicine 2015; 15 (5) . https://dx.doi.org/10.2174/1566524015666150630124447
DOI https://dx.doi.org/10.2174/1566524015666150630124447 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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