Peroxisome proliferator-activated receptor γ (PPARγ) is a versatile member of the ligandactivated
nuclear hormone receptor superfamily of transcription factors, with expression in several different
cell lines, especially in the digestive system. After being activated by its ligand, PPARγ can
suppress the growth of oral, esophageal, gastric, colorectal, liver, biliary, and pancreatic tumor cells,
suggesting that PPARγ ligand is a potential anticancer agent in PPARγ-expressing tumors. This review
highlights key advances in understanding the effects of PPARγ ligands in the treatment of tumors in
the digestive system.
Keywords: Antitumor, chemoprevention, digestive system, peroxisome proliferator-activated receptor γ, thiazolidinediones
(TZDs), tumor cells.
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