Abstract
Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.
Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.
Letters in Organic Chemistry
Title:Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives
Volume: 12 Issue: 8
Author(s): Takuma Yoshida, Lei Wang, Shiori Nakagawa, Zetryana Puteri Tachrim, Yasuko Sakihama, Yasuyuki Hashidoko and Makoto Hashimoto
Affiliation:
Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.
Abstract: Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.
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Cite this article as:
Yoshida Takuma, Wang Lei, Nakagawa Shiori, Tachrim Puteri Zetryana, Sakihama Yasuko, Hashidoko Yasuyuki and Hashimoto Makoto, Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives, Letters in Organic Chemistry 2015; 12 (8) . https://dx.doi.org/10.2174/1570178612666150629181357
DOI https://dx.doi.org/10.2174/1570178612666150629181357 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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