Synthesis of Cross-linkable 2,5-Diketopiperazine Derivatives

Author(s): Takuma Yoshida, Lei Wang, Shiori Nakagawa, Zetryana Puteri Tachrim, Yasuko Sakihama, Yasuyuki Hashidoko, Makoto Hashimoto.

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 8 , 2015

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Graphical Abstract:


Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine. No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the construction of diketopiperazine skeleton.

Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.

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Article Details

Year: 2015
Page: [544 - 548]
Pages: 5
DOI: 10.2174/1570178612666150629181357
Price: $58

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