Synthesis of cross-linkable diketopiperadine derivatives is described. Cross-linkable aamino
acid methyl esters were subjected to peptide synthesis with Boc-protected glycine or L-tyrosine.
No protection of cross-linkable functional groups (catechol and phenylazide) is necessary for the
construction of diketopiperazine skeleton.
Keywords: Cross-link, cyclic dipeptide, diketopiperazine, DOPA, phenylazide, photoaffinity label.
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