Self-assembling Peptide Nanofibers Containing D-amino Acids for Tetrandrine Delivery

Author(s): Qian Liu, Xiaoyong Yi, Xiaomeng Hu.

Journal Name: Current Signal Transduction Therapy

Volume 10 , Issue 2 , 2015

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Abstract:

Self-assembling peptides have very recently emerged as a new class of drug vehicles, as they hold unique advantages such as good biocompatibility, design flexibility, and controllable nanotructure. In this work, we report a self-assembling peptide containing D-amino acids (Nap- GDFDFDYGRGD) as the carrier of anticancer drug tetrandrine. Tetrandrine is a bis-benzylisoquinoline alkaloid isolated from the root of Hang-Fang-Chi (Stephania tetrandra S. Moore). The D-peptides were employed in this study as they have shown stronger resistance against proteases than their Lcounterpart with natural L-amino acids. The Nap-GDFDFDYGRGD peptides can self-assemble into nanofibers, which are able to efficiently encapsulate tetrandrine. The drug-loaded nanofibers are capable of sustained release of tetrandrine and being internalized by the LoVo cancer cells. The cytotoxicity studies indicate that the tetrandrine-loaded nanofibers possess similar cytotoxicity to free tetrandrine against LoVo cancer cells and the Nap- GDFDFDYGRGD nanofibers can be used as a safe vehicle.

Keywords: D-Amino acid, drug carrier, drug delivery, peptide, self-assembly, tetrandrine.

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Article Details

VOLUME: 10
ISSUE: 2
Year: 2015
Page: [83 - 88]
Pages: 6
DOI: 10.2174/1574362410666150625190853
Price: $58

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