The impacts of air pollution on human health and disease have been attracting attention,
especially in industrialized countries and areas with heavy traffic burdens. Fine particulate matters
(PMs) are considered as an important air pollutant, since it was reported that there was a significant
relationship between PM2.5 levels and mortality by cohort studies in 1990s. Epidemiological and
toxicological studies have strongly suggested a causative relationship between fine particulate air pollution
and increased incidence as well as exacerbations of asthma, and other respiratory disorders. Recent advances in research
have elucidated that PMs primarily and secondarily induce oxidative stresses which result both in pro- and antiinflammatory
activities. It has been demonstrated that gene polymorphisms of antioxidant enzymes might change responses
to particulate air pollution exposures. To prevent health hazardous effects of particles, it is crucial to screen susceptible
subpopulations and establish chemoprevention strategies in the world. Novel techniques and modalities are patented
for future progress on better control of air pollution.
Keywords: Air pollutants, antioxidant enzyme, bronchial asthma, diesel exhausts, gene-environmental interaction, oxidant
stress, particulate matters.
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