Reshaping the Protein Folding Pathway by Osmolyte via its Effects on the Folding Intermediates

Author(s): Gurumayum Suraj Sharma, Tanveer Ali Dar, Laishram Rajendrakumar Singh.

Journal Name: Current Protein & Peptide Science

Volume 16 , Issue 6 , 2015

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Abstract:

It is now well established that the protein folding reaction proceeds via accumulation of various intermediate states. Osmolytes, besides their role in protein stabilization, have also been shown to possess the ability of inducing tremendous affects on these protein folding intermediates, reshape the folding pathway and the energy landscape. The present article describes the advances made so far in understanding the effects of organic osmolytes on the folding intermediates and pathways. The ability of osmolytes to rescue disease causing mutations in proteins by inducing proper folding into functionally active form is also discussed. Finally, some future directions are described.

Keywords: Folding kinetics, molten globule, native-like, osmolytes, protein folding, protein folding intermediates.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2015
Page: [513 - 520]
Pages: 8
DOI: 10.2174/1389203716666150623104330
Price: $58

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