Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin

Title:Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin

Volume: 22 Issue: 8

Author(s): Liqian Gao, Zhiqiang Yu, Dan Meng, Fang Zheng, Yong S. Ong, Peng Miao, Su S. Lee and Longping Wen

Affiliation:

Keywords: Antagonist, F peptide, frog skin, Melanophore Index, melanotropic activity, MTII peptide.

Abstract: An α-MSH peptide analogue, named MTII (Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]- NH2), is one of the most important ligands of melanotropic receptors but are relatively nonselective. In order to improve the melanotropic activities of the well-characterized MTII analogues, we report here a new analogue by modifying the core structure as well as the size of the cyclic region of MTII peptide. The analogue peptide, Ac-Nle-c[Asp-His-D-Phe-Lys-Trp-Gly-Lys]-OH (F Peptide), in which we replaced Arg at position 8 with Lys and added a Gly to position 10 of the MTII peptide sequence, was synthesized and used as a new melanotropic hormone in controlling rapid color changes in frogs by its actions on mobilizing pigment granule movements within chromatophores. The in vivo responses of chromatophores to MTII and the related analogue F Peptide were studied in frogs. The results show that the F Peptide was a superpotent agonist with similar melanotropic activity to the MTII peptide according to MTII peptide by in vivo studies. The analogue also exhibited ultraprolonged melanotropic activity. The F peptide can be useful in the study of numerous physiological processes, particularly when superpotent and prolonged melanotropic activity is desired.

Cite this article as:

Gao Liqian, Yu Zhiqiang, Meng Dan, Zheng Fang, Ong S. Yong, Miao Peng, Lee S. Su and Wen Longping, Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin, Protein & Peptide Letters 2015; 22 (8) . https://dx.doi.org/10.2174/0929866522666150622101944