Curcumin is the yellow-colored bioactive constituent of the perennial plant, Curcuma longa
L., which possesses a wide range of physiological and pharmacological properties such as antioxidant,
anti-inflammatory, anticancer, neuroprotective and anti-diabetic activities. Anti-diabetic activity of curcumin may be due
to its potent ability to suppress oxidative stress and inflammation. Moreover, it shows a beneficial role on the diabetesinduced
endothelial dysfunction and induces a down-regulation of nuclear factor-kappa B. Curcumin possesses a protective
role against advanced glycation as well as collagen crosslinking and through this way, mitigates advanced glycation
end products-induced complications of diabetes. Curcumin also reduces blood glucose, and the levels of glycosylated hemoglobin
in diabetic rat through the regulation of polyol pathway. It also suppresses increased bone resorption through
the inhibition of osteoclastogenesis and expression of the AP-1 transcription factors, c-fos and c-jun, in diabetic animals.
Overall, scientific literature shows that curcumin possesses anti-diabetic effects and mitigates diabetes complications.
Here we report a systematical discussion on the beneficial role of curcumin on diabetes and its complications with emphasis
on its molecular mechanisms of actions.