Islet Compensation in Metabolic Stress: Lessons from Animal Models

Author(s): Himadri Singh.

Journal Name: Current Diabetes Reviews

Volume 12 , Issue 4 , 2016

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Abstract:

Type 2 diabetes is characterized by decreased functional beta-cell mass, as a consequence of metabolic stress associated with obesity, aging, insulin resistance and pregnancy. The metabolic stress is caused by increased insulin demand, pro-inflammatory cytokines, and free fatty acids. Fortunately, islets have remarkable property to adapt to increased metabolic demand. This review focuses on the mechanisms of islet adaptation to metabolic stress in obesity and insulin resistance

Keywords: Islets, adaptation, hypertrophy, epigenetics, beta-cells, models.

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Article Details

VOLUME: 12
ISSUE: 4
Year: 2016
Page: [315 - 321]
Pages: 7
DOI: 10.2174/1573399811666150617161915
Price: $58

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