This paper reports on the asymmetric reduction of 2,2,2-trifluoro-1-phenylethanone 1a to
the corresponding (S)-2,2,2-trifluoro-1-phenylethanol 1b by marine fungus M. racemosus CBMAI 847
under conventional heating (CH) and microwave radiation (MW). The results show that (S)-alcohol
was obtained with good conversion (64-100%) and enantiomeric excess (74-99%) for both methods
performed under conventional heating (orbital shaking) and microwave radiation. When 2,2,2-
trifluoro-1-phenylethanone 1a was reduced by fungus under microwave radiation, the methodology showed to be very efficient
to obtain enantiomerically pure alcohol 1b in comparison to the conventional heating. This is the first report on the
use of microwave-assistant in biocatalytic reactions catalyzed by marine fungus.
Keywords: Biocatalysis, bioreduction, fluoroketone, microwave radiation, Mucor racemosus, whole cells.Biocatalysis, bioreduction, fluoroketone, microwave radiation, Mucor racemosus, whole cells.
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