Anti-Cancer Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Michelle Prudhomme  
Universite Blaise Pascal - C.N.R.S
Aubiere Cedex
France

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A Novel Cobalt(II) Coordination Complex Constructed from H2Pyri and 4,4′-Bipy: Synthesis, Characterization and Bioactivity

Author(s): Enjun Gao, Fuchen Zhao, Mingchang Zhu, Meilin Wang.

Graphical Abstract:


Abstract:

The new complex of {[Co(4,4′-Bipy)(H2O)4]·(Pyri)·3H2O}n (4,4′-Bipy = 4,4′-bipyridyl, H2Pyri = 3,5- Pyridinedicarboxylic acid) was synthesized and characterized by IR, element analysis and X-ray single-crystal diffraction. The binding of the complex with extracted HeLa cells DNA was investigated by UV and fluorescence spectrum. Gel electrophoresis assay demonstrated the ability of the complex cleaving the extracted HC-DNA. The complex exhibited a higher cytotoxicity against tumor cells in vitro. Furthermore, the apoptotic tests indicated the complex had an apoptotic effect on HeLa cells.

Keywords: apoptosis, Cobalt(II) complex, cytotoxicity, gel electrophoresis.

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Article Details

VOLUME: 15
ISSUE: 6
Year: 2015
Page: [783 - 792]
Pages: 10
DOI: 10.2174/187152061506150610152136
Price: $58