Catalytic Enantioselective Constructions of Trifluoromethylated Chiral Stereogenic Centers via the Conjugate Addition to CF3-Alkenes: Overview of Current Progress

Author(s): Kazutaka Shibatomi.

Journal Name: Current Organic Chemistry

Volume 19 , Issue 16 , 2015

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Graphical Abstract:


Synthetic methods for the enantioselective constructions of trifluoromethylated stereogenic centers are described. In particular, this review focuses on recent examples of catalytic enantioselective transformations with trifluoromethyl alkenes. These reactions efficiently synthesized chiral compounds with trifluoromethylated stereogenic centers.

Keywords: Trifluoromethyl group, enantioselective synthesis, chiral catalyst, conjugate addition, Diels-Alder reaction, trifluoromethyl alkenes

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Article Details

Year: 2015
Page: [1619 - 1637]
Pages: 19
DOI: 10.2174/1385272819666150608222305
Price: $58

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