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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Catalytic Enantioselective Constructions of Trifluoromethylated Chiral Stereogenic Centers via the Conjugate Addition to CF3-Alkenes: Overview of Current Progress

Author(s): Kazutaka Shibatomi

Volume 19, Issue 16, 2015

Page: [1619 - 1637] Pages: 19

DOI: 10.2174/1385272819666150608222305

Price: $65

Abstract

Synthetic methods for the enantioselective constructions of trifluoromethylated stereogenic centers are described. In particular, this review focuses on recent examples of catalytic enantioselective transformations with trifluoromethyl alkenes. These reactions efficiently synthesized chiral compounds with trifluoromethylated stereogenic centers.

Keywords: Trifluoromethyl group, enantioselective synthesis, chiral catalyst, conjugate addition, Diels-Alder reaction, trifluoromethyl alkenes

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