The biological activities of the calix[n]arenes have been extensively reported on, with regard to various
forms of life ranging from self-replicating systems, such as, viruses, through bacteria, fungi and mammalian cells
to human beings. This article reviews more than one hundred different calix[n]arenes classified according to their
biological effects directly observed on living species. These macrocyclic molecules have been reported as detoxifying
agents, as having antibacterial, antiviral, anticoagulant, anticancer, antifungal activities, as membrane protein
modulators / extracters, drug transporters and fluorescent probes. Special in vivo sections, have been inserted when
possible for each biological effect showing the impact of the calix[n]arenes on whole living system such as animals or humans.