Considerable number of nitrogen containing active pharmaceutical ingredients and natural
products are frequently synthesized from optically pure β-amino ketones, aldehydes, esters, and alcohols.
Synthesis of 1,3-amino ketones, aldehydes, alcohols and esters engages Mannich-type reactions,
the most important basic reaction-types in organic chemistry. The current trend in the development of
asymmetric Mannich-type reaction is to employ unmodified ketones and aldehydes as starting materials
in the presence of simple and easily accessible metal-free organocatalysts under mild and convenient
reaction conditions. Although L-Proline and its derivatives are commonly and extensively studied
organocatalysts in Mannich reactions, many other organocatalysts based on bifunctional thiourea, chiral Bronsted acids
and some other organocatalytic systems are also equally effective. The present review comprehensively describes an
overview of asymmetric Mannich reactions under different organocatalytic systems in both organic and aqueous media.
Keywords: Aminoalkylation, asymmetric synthesis, aqueous media, C-C bond formation, chiral bronsted acids, Mannich reaction,
organic media, organocatalysis, L-proline, thioureas.
Rights & PermissionsPrintExport