Kinetic Modeling for the Main Metabolic Pathways
Pp. 133-186 (54)
Kazuyuki Shimizu and Yu Matsuoka
Kinetic models for the main metabolic pathways such as glycolysis, TCA
cycle, pentose phosphate pathway together with anaplerotic pathways and
gluconeogenic pathways are explained. Kinetic models for substrate uptake pathways
such as glucose PTS, glycerol uptake pathways, and xylose assimilating pathways are
then explained. Kinetic models for the fermentation pathways under anaerobic condition
are also explained. Moreover, kinetic models for amino acid synthetic pathways such as
glutamic acid/ glutamine synthetic pathways and lysine synthetic pathways are
explained. Unlike flux balance analysis based on the stoichiometric constraints, kinetic
modeling approach based on enzymatic reactions for the metabolic pathways can be
easily extended for the inclusion of enzyme level and transcriptional regulations, and
the kinetic models can reasonably express the dynamics.
Kinetic modeling, Embden-Meyerhoff-Parnas pathway, glycolysis,
pentose phosphate pathway, TCA cycle, gluconeogenic pathway, amino acid
synthesis, carbohydrate metabolism, nitrogen metabolism, anaerobic fermentation,
lysine synthetic pathway.
Institute of Advanced Biosciences Keio University Tsuruoka Yamagata 997-0017 Japan.