Cancer is the major cause of fatality and the number of new cases is increasing incessantly.
Conventional therapies and existing anticancer agents cause serious side effects and expand the patient’s
lifespan by a few years. There is the need to exploit alternative anticancer agents and novel drug
delivery system to deliver these agents to the tumor site for the prevention of cancer. Recently, biologically
active compounds isolated from plants used for the management of cancer have been the
heart of interest. Capsaicin is a major pungent agent present in the chili peppers that is heavily consumed in the world.
Capsaicin has demonstrated effectiveness as an anticancer agent, but a restraining factor is its pungency, extremely low
aqueous solubility, and poor oral bioavailability which impede its use as an anticancer agent. Many technologies have
been developed and applied to conquer this drawback. We bring to light the benefits of this phytoconstituent for treating
different types of cancer. We also discussed some of the delivery approaches that have already made an impact by either
delivering a drug to target tissue or increasing its bioavailability by many folds.
Keywords: Bioavailability, capsaicin, cancer, drug delivery, nanotechnology, novel drug carrier.
Rights & PermissionsPrintExport