Alpha and Theta Rhythms Activity is Associated to Morpho- Structural and Perfusional Modifications in Subjects with Prodromal Alzheimer`s Disease
Pp. 3-19 (17)
Vito Davide Moretti, Prestia A, Binetti G, Zanetti O and Frisoni G B
The increase in EEG alpha3/alpha2 frequency power ratio has been
associated with AD-converters subjects with mild cognitive impairment (MCI) as well
as a reduction in the regional cerebral blood flow (rCBF).
In this study, the association between alpha3/alpha2 frequency power ratio with rCBF
changes in subjects with MCI was evaluated.
The alpha3/alpha2 frequency power ratio was computed in 27 subjects with MCI. Two
groups were obtained according to the median values of alpha3/alpha2, at a cut-off
value of 1.17. In the groups so obtained, the correlation between brain perfusion and
EEG markers was detected.
In the MCI group with the alpha3/alpha2 frequency power ratio above 1.17 as compared
to the group with alpha3/alpha2 frequency power ratio below 1.17 there were: 1) a
constant trend to lower rCBF values; 2) smaller hippocampal volumes; and 3) higher
theta frequency power.
The higher EEG alpha3/alpha2 frequency power ratio individuates two different groups
of MCI subjects. A complex interplay between alpha and theta rhythms activity MCI
patients is suggested in patients with prodromal Alzheimer`s disease.
Alpha rhythm, EEG, MRI, SPECT, Theta rhythm.
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