A series of piperamides (PA) 8a-j were designed, synthesized and evaluated for their antimicrobial
and anticonvulsant activity. Compounds 8a and 8h showed considerable antibacterial activity
against B. subtilis with minimum inhibitory concentration (MIC) of 8 and 10 µg/mL, respectively.
Compounds 8a and 8h showed advanced anticonvulsant activity as well as lower neurotoxicity than the reference drugs.
The interaction between bovine serum albumin (BSA) and PA was investigated using fluorescence quenching and UV-vis
absorption spectroscopy. Results showed that PA could strongly quinch the intrensic fluorescence of BSA through a static
quencing procedure. The binding constant and number of binding sites of PA with BSA were obtained. The binding distance
was calculated based on Forster non-radiative energy transfer theory.
Keywords: Anticonvulsant, bovine serum albumin, fluorescence quenching, piperamide.
Rights & PermissionsPrintExport