Advances in Hyaluronic Acid-Based Drug Delivery Systems

Author(s): Yan Jiao, Xin Pang, Guangxi Zhai.

Journal Name: Current Drug Targets

Volume 17 , Issue 6 , 2016

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Abstract:

Hyaluronic acid (HA) is a relatively new polymer for the construction of drug delivery systems. CD44 and the receptor for HA-mediated motility play a key role in vivo for the receptormediated endocytosis of HA. Cellular uptake and the efficiency of tumor-targeted drug delivery are supposed to increase through utilizing HA as drug carriers. Currently, HA has provided a promising platform to physically encapsulate or chemically conjugate with various drugs. In this review, we presented the most latest advances in HA-based drug delivery systems and some forward-looking ideas are discussed.

Keywords: CD44, chemical modification, conjugates, derivatives, hyaluronic acid, nanocarriers.

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Article Details

VOLUME: 17
ISSUE: 6
Year: 2016
Page: [720 - 730]
Pages: 11
DOI: 10.2174/1389450116666150531155200
Price: $58

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