Current Computer-Aided Drug Design

Subhash C. Basak
Departments of Chemistry, Biochemistry & Molecular Biology University of Minnesota Duluth
Duluth, MN 55811
USA

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Development of Global Consensus of Dengue Virus Envelope Glycoprotein for Epitopes Based Vaccine Design

Author(s): Mazhar Hussain, Muhammad Idrees, Samia Afzal.

Abstract:

Dengue virus (DENV) is the member of Flaviviridae and causative agent of Dengue Haemorrhagic Fever and Dengue Shock Syndrome. Every year, around 70% of the world population is at risk, due to epidemic episodes orchestrated by one or more of its serotypes. So, a tetravalent DENV vaccine is needed which may induce the immune response against all four DENV serotypes. In this study, B-cell and T-cell epitopes have been predicted from the DENV envelope glycoprotein (Eg) using a consensus based approach in complement with the physico-chemical property (PCP) conservancy analysis. Through DENV-Eg analysis, a total of 7 PCP conserved, water soluble, in vitro and in vivo stable epitopes were predicted which may induce the B-cell and T-cell mediated anti-viral immune response.

Keywords: Dengue virus, consensus sequence, Envelope glycoprotein, phylogenetic analysis, in silico design.

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Article Details

VOLUME: 11
ISSUE: 1
Year: 2015
Page: [84 - 97]
Pages: 14
DOI: 10.2174/1573409911666150529130134
Price: $58