Epigenetic Regulation of Osteogenic Differentiation of Mesenchymal Stem Cells

Author(s): Gang Fu , Aishu Ren , Yu Qiu , Yi Zhang .

Journal Name: Current Stem Cell Research & Therapy

Volume 11 , Issue 3 , 2016

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Abstract:

Mesenchymal stem cells (MSCs) are multipotent progenitors that have the abilities of selfrenewal and multiple direction differentiation. The osteogenic potential of MSCs holds great promise for bone defect repair and bone disease treatment. For a long time studies about osteogenic differentiation of MSCs have emphasized on the effect of extrinsic regulators and the corresponding transcription factors controlling cell fate. In fact, cell fate is determined by lineage specific gene expression that is regulated more specifically by epigenetic mechanism. Over the last decade, some progress has been made in epigenetic researches of MSCs osteogenic differentiation. DNA methylation, histone modifications and microRNA (miRNA) are all verified important mechanisms regulating MSCs differentiation. Epigenetic regulation might provide novel treatment targets for promoting bone formation. In this review, we will summarize the recent advance about the epigenetic mechanism that control MSCs commitment to osteoblasts and the potential clinical application of MSCs epigenetics in future.

Keywords: DNA methylation, epigenetic, histone modification, mesenchymal stem cells, microRNA, osteogenic differentiation.

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2016
Page: [235 - 246]
Pages: 12
DOI: 10.2174/1574888X10666150528153313
Price: $58

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