Liquid Chromatographic, Spectrophotometric and Potentiometric pKa Determination of Ranitidine and Famotidine

Author(s): Y. Dogan Daldal, Cansel Cakır, Hulya Yılmaz, Ebru Cubuk Demiralay, Sibel A. Ozkan, Guleren Alsancak.

Journal Name: Current Drug Therapy

Volume 9 , Issue 4 , 2014

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Graphical Abstract:


The dissociation constant (pKa) is one of the most significant properties of a substance chemical moiety which has to be estimated with accuracy. Liquid chromatographic, spectrophotometric and potentiometric methods are often employed for determination of pKa values of compounds. This study describes the practice of these three methods to the determination of dissociation constant values of famotidine and ranitidine in acetonitrile-water binary mixtures. From these constants, aqueous dissociation constants of investigated substances were calculated by different approaches.

Moreover, estimation of aqueous pKa values ( wwpKa ) can also be predicted by computational

method (Marvin Sketch) on the basis of molecular structure. Results obtained from wwpKa values are compared with Marvin Sketch program and literature values.

Keywords: Acetonitrile-water mixtures, aqueous pKa value, dissociation constant, H2 receptor antagonists, molecular structure, RPLC.

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Article Details

Year: 2014
Page: [277 - 284]
Pages: 8
DOI: 10.2174/157488550904150525164412
Price: $58

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