Environmentally Benign Synthetic Protocol for the Synthesis of Spiroquinazolinones Using Sustainable and Recyclable Choline Chloride Based Deep Eutectic Mixture

Author(s): Yogesh Kumar Tailor, Sarita Khandelwal, Hemant Kumar Jain, Mahendra Kumar.

Journal Name: Current Organic Synthesis

Volume 12 , Issue 4 , 2015

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Abstract:

Diversity oriented, efficient and environmentally benign synthetic protocol has been presented for the synthesis of spiroquinazolinones. The hybrid drug-like small molecules incorporating medicinally privileged heterocyclic systems have been synthesized by tandem reaction of 3-aminocrotonnitrile, phenyl hydrazine/ hydrazine hydrate, isatoic anhydride and isatin using deep eutectic solvent as efficient catalyst and environmentally benign reaction medium.

Keywords: Deep eutectic solvent, HBD (Hydrogen bond donor), Ionic liquid, Tandem reaction, Privileged heterocyclic structure, Spiroquinazolinone.

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Article Details

VOLUME: 12
ISSUE: 4
Year: 2015
Page: [484 - 491]
Pages: 8
DOI: 10.2174/157017941204150522190425
Price: $58

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