Fluoroquinolone and Ovariectomy in the Bitch: Physiology of the Immune System as to CD56 and CD16 Expression

Author(s): Maria Albrizio , Annalisa Rizzo , Marianna Pantaleo , Fabrizio Pampurini , Mariagrazia Piccinno , Raffaele Luigi Sciorsci .

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 15 , Issue 2 , 2015

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Abstract:

Natural killer (NK) cells are innate lymphoid cells which act against a variety of pathogens and tumours. Phenotypically they are characterized by surface markers named cluster designation (CD) antigens. CD56 and CD16 are recognized as specific NK markers in the dogs as well as in humans. Surgical interventions suppress NK cells both in rats and humans. In this direction, it has been shown that an antibiotic regimen (amoxicillin, benzylpenicillin/dihydrostreptomycin, sulfametazine/sulfamerazine/ sulfathiazole, enrofloxacin, lincomycin/spectinomycin) administered only twice is effective in preventing infections after laparatomic ovariectomy, in the bitch. On these grounds, this research will show that the administration of a fluoroquinolone (5 mg/kg of enrofloxacin, Baytril®, Bayer, Milan, Italy) one hour before and at the end of ovariectomy is able to increase CD56 and CD16 expression levels. Moreover, the antibiotic administration modifies the relative expression levels of the two CD; thus suggesting that the fluoroquinolone employed enhances the activation of a specific subset of NK cells mainly involved in body recovering during the post operative period as already observed in humans.

Keywords: Bitch, CD16, CD56, fluoroquinolone, NK cells, ovariectomy.

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Article Details

VOLUME: 15
ISSUE: 2
Year: 2015
Page: [159 - 168]
Pages: 10
DOI: 10.2174/187153031502150522122853
Price: $58

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