Ferulic Acid and Alzheimer’s Disease: Promises and Pitfalls

Author(s): Seyed Fazel Nabavi , Kasi Pandima Devi , Dicson Sheeja Malar , Antoni Sureda , Maria Daglia , Seyed Mohammad Nabavi .

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 15 , Issue 9 , 2015

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Abstract:

Oxidative stress plays an important role in both initiation and progression of neurodegenerative diseases, such as Alzheimer and Parkinson. Therefore, much attention has been paid to antioxidants for developing therapeutic strategies for the neurodegenerative diseases. However, as serious adverse effects are related to synthetic antioxidants, recent research has been focused on natural products especially phenolic antioxidants. In the present article, we critically review the available literature related to the beneficial role of ferulic acid on Alzheimer’s disease, since it is a natural antioxidant which is widely found in different fruits and vegetables. We also provide some informations about sources, chemical structure, bioavailability and clinical impacts of ferulic acid.

Keywords: Alzheimer’s disease, antioxidant, ferulic acid, neurodegeneration, oxidative stress.

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Article Details

VOLUME: 15
ISSUE: 9
Year: 2015
Page: [776 - 788]
Pages: 13
DOI: 10.2174/1389557515666150522102545
Price: $58

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