Fibromyalgia (FM) is a characterized by generalized pain with widespread tender points in
specific areas and is frequently accompanied by fatigue, stiffness, and a non-restorative sleep pattern.
In the current retrospective study, we identified a subgroup of FM patients who had clinically important
markers of inflammation. The study also explored the use of the original American College of
Rheumatology (ACR) criteria in the diagnosis of FM. Our data suggested there was a distinct subset
of patients with FM who had positive ESR, CRP, ANA and RF; a group that we considered representative
of inflammatory FM. None of the FM patients in this study developed a documented coexisting
autoimmune illness during the retrospective review period. The existence of FM subgroups further puts into question the
already controversial use of either the new or old ACR classification criteria in the diagnosis of FM, as they do not address
the issue of systemic inflammation which appears to be significant.
Keywords: ACR, autoimmune, inflammatory markers, diagnosis.
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