The role of oral bacteria in the etiology of ankylosing spondylitis (AS) is examined in this
review. Periodontitis is related to AS to a significant degree, and periodontitis is significantly more
prevalent in patients with AS. Anti-Pophyromonas gingivalis and anti-Prevotella intermedia antibodies
titers are higher in AS patients than in healthy subjects. Eight randomized controlled trials that
used sulfasalazine were reviewed. Moxifloxacin and rifamycin are significantly effective in the treatment
of AS. Periodontal pathogens are likely to be responsible for the development of AS in genetically
susceptible individuals. These results will guide more comprehensive and efficacious treatment
strategies for AS.
Keywords: Ankylosing spondylitis, arginine, etiology, oral bacteria.
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