Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence


Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis

Author(s): Mesut Ogrendik.


The role of oral bacteria in the etiology of ankylosing spondylitis (AS) is examined in this review. Periodontitis is related to AS to a significant degree, and periodontitis is significantly more prevalent in patients with AS. Anti-Pophyromonas gingivalis and anti-Prevotella intermedia antibodies titers are higher in AS patients than in healthy subjects. Eight randomized controlled trials that used sulfasalazine were reviewed. Moxifloxacin and rifamycin are significantly effective in the treatment of AS. Periodontal pathogens are likely to be responsible for the development of AS in genetically susceptible individuals. These results will guide more comprehensive and efficacious treatment strategies for AS.

Keywords: Ankylosing spondylitis, arginine, etiology, oral bacteria.

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Article Details

Year: 2015
Page: [47 - 49]
Pages: 3
DOI: 10.2174/1573397111666150522094821