Two efficient synthetic routes to (S,S)-ethambutol, a first line drug used for tuberculosis
treatment, based on the chiral pool approach viewing L-methionine as a starting material are reported.
Several advantages over the traditional synthetic routes were observed: simple, safe, inexpensive
reagents, and minimum byproduct formation. The key intermediate (S)-(+)-2-amino-1-butanol was
obtained in its enantiomerically pure form from the corresponding aminobutyric acid.
Keywords: Drugs, L-methionine, 1, 2-diamine, (S)-(+)-2-amino-1-butanol, (S, S)-ethambutol, tuberculosis.
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