An Environmentally Friendly, Scalable and Highly Efficient Synthesis of (S,S)-Ethambutol, a First Line Drug against Tuberculosis

Author(s): Raoni S.B. Goncalves, Emerson T. da Silva, Marcus Vinicius N. de Souza.

Journal Name: Letters in Organic Chemistry

Volume 12 , Issue 7 , 2015

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Abstract:

Two efficient synthetic routes to (S,S)-ethambutol, a first line drug used for tuberculosis treatment, based on the chiral pool approach viewing L-methionine as a starting material are reported. Several advantages over the traditional synthetic routes were observed: simple, safe, inexpensive reagents, and minimum byproduct formation. The key intermediate (S)-(+)-2-amino-1-butanol was obtained in its enantiomerically pure form from the corresponding aminobutyric acid.

Keywords: Drugs, L-methionine, 1, 2-diamine, (S)-(+)-2-amino-1-butanol, (S, S)-ethambutol, tuberculosis.

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Article Details

VOLUME: 12
ISSUE: 7
Year: 2015
Page: [478 - 481]
Pages: 4
DOI: 10.2174/1570178612666150521235908
Price: $58

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