Recent Advances in the Membrane Receptor Initiated Vitamin D Signaling of Calcium and Phosphate Transport Across Intestinal and Kidney Epithelia

Title:Recent Advances in the Membrane Receptor Initiated Vitamin D Signaling of Calcium and Phosphate Transport Across Intestinal and Kidney Epithelia

VOLUME: 14 ISSUE: 3

Author(s):Ramesh C. Khanal, Yang Zhang and Ilka Nemere

Affiliation:Utah State University, 8700 Old Main Hill, Logan, UT 84322-8700, USA.

Keywords:Calcium, phosphate, vitamin D, 1, 25D₃-MARRS receptor, ERp57/GRp58, cancer, Alzheimer’s.

Abstract:The 1,25D₃-MARRS receptor is bioidentical with protein disulfide isomerase A3, and has been demonstrated to be required for the rapid, pregenomic actions of the steroid hormone 1,25D₃ on calcium and phosphate uptake in a number of tissues. In this review we discuss the role of this receptor as it relates to the recent advances in calcium and phosphate transport along with its role in select disease states. We also review that another metabolite, 24,25D₃, also has biological activity.

Cite this article as:

Ramesh C. Khanal, Yang Zhang and Ilka Nemere, “Recent Advances in the Membrane Receptor Initiated Vitamin D Signaling of Calcium and Phosphate Transport Across Intestinal and Kidney Epithelia”, Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization) (2014) 14: 171. https://doi.org/10.2174/187152221403150521110022

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