Cyathane diterpenoids, occurring exclusively in higher basidiomycete (mushrooms), represent
a structurally diverse class of natural products based on a characteristic 5-6-7 tricyclic carbon
scaffold, including 105 members reported to date. These compounds show a diverse range of biological
activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, antiinflammatory,
anti-proliferative and nerve growth factor (NGF)-like properties. The present review focuses
on the structure diversity, structure elucidation and biological studies of these compounds, including
mechanisms of actions and structure-activity relationships (SARs). In addition, new progress in chemical synthesis
of cyathane diterpenoids is discussed.
Keywords: Basidiomycete, cyathane diterpenes, enantioselective synthesis, mushroom, natural products, NGF synthesis inducers, structure-activity relationships.
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