Recent Advances in C-H Trifluoromethylthiolation and Trifluoromethoxylation Reactions

Author(s): Jin-Hong Lin , Yun-Long Ji , Ji-Chang Xiao .

Journal Name: Current Organic Chemistry

Volume 19 , Issue 16 , 2015

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Graphical Abstract:


As both trifluoromethylthio (CF3S) and trifluoromethoxy (CF3O) moieties have proved to be valuable functionalities in pharmaceutical chemistry, trifluoromethylthiolation and trifluoromethoxylation have received a great deal of attention. For the trifluoromethylthiolation reaction, a variety of efficient methods have been developed. Among these methods, C-H trifluoromethylthiolation avoids the need to prefunctionalize substrates, meaning that this straightforward protocol is quite attractive and promising. The first section of this review summarizes recent advances in this field, including Csp3-H, Csp2-H and Csp-H trifluoromethylthiolation and the asymmetric Csp3-H trifluoromethylthiolation reactions. Trifluoromethoxylation with safe trifluoromethoxylation reagents remains a significant challenge. The second section of this review summarizes the recent progress in trifluoromethoxylation reaction.

Keywords: C-H bond, trifluoromethylthiolation, asymmetric trifluoromethylthiolation, trifluoromethoxylation, trifluoromethoxylation reagent, fluorine.

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Article Details

Year: 2015
Page: [1541 - 1553]
Pages: 13
DOI: 10.2174/1385272819666150520230727
Price: $58

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