An Overview of Interleukin-17A and Interleukin-17 Receptor A Structure, Interaction and Signaling

Author(s): Jelena Krstic , Hristina Obradovic , Tamara Kukolj , Slavko Mojsilovic , Ivana Okic-Dordevic , Diana Bugarski , Juan F. Santibanez .

Journal Name: Protein & Peptide Letters

Volume 22 , Issue 7 , 2015

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Abstract:

Interleukin-17A (IL-17A) and its receptor (IL-17RA) are prototype members of IL-17 ligand/receptor family firstly identified in CD4+ T cells, which comprises six ligands (IL-17A to IL- 17F) and five receptors (IL-17RA to IL-17RE). IL-17A is predominantly secreted by T helper 17 (Th17) cells, and plays important roles in the development of autoimmune and inflammatory diseases. IL-17RA is widely expressed, and forms a complex with IL-17RC. Binding of IL-17A to this receptor complex triggers the activation of several intracellular signaling pathways. In this review, we aimed to summarize literature data about molecular features of IL-17A and IL-17RA from gene to mature protein. We are also providing insight into regulatory mechanisms, protein structural conformation, including ligand-receptor interaction, and an overview of signaling pathways. Our aim was to compile the data on molecular characteristics of IL-17A and IL-17RA which may help in the understanding of their functions in health and disease.

Keywords: Expression, Interleukin-17, interleukin-17 receptor A, receptor interaction, regulation, signaling pathways.

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Article Details

VOLUME: 22
ISSUE: 7
Year: 2015
Page: [570 - 578]
Pages: 9
DOI: 10.2174/0929866522666150520145554
Price: $58

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