Vitamin D has an indisputable immunodulatory role in both lung and immune system
development, which is initiated during fetal life and is mainly accomplished in the first years of
extrauterine life. Several published studies have shown that low levels of vitamin D may increase the
risk of developing asthma and allergic diseases. Moreover, vitamin D deficiency epidemic reported
over the last decades coincides with an increase in the prevalence of asthma and allergies in
westernized societies. Since placental transfer of 25(OH)D is the major source of vitamin D in the
developing fetus, important questions concerning the impact of maternal vitamin D status on the
outcome of pregnancy have arisen. The aim of this review is to present the current evidence regarding the determinants of
vitamin D status in pregnancy as well as its role in the development of asthma and allergies in early childhood.
Keywords: Allergic disease, asthma, immunity, pregnancy, vitamin D, 25(OH)D.
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