Abstract
Polymer drug conjugates play an important role in the delivery of drugs. In the polymeric drug conjugates, the bioactive agent is combined covalently with polymer to achieve the efficient delivery of bioactive agents in the required or specific period of time along with the enhancement of permeability and retention time. A large number of biodegradable polymers have been widely used in the area of biomedical science. Among them, polyphosphazene, is a biodegradable polymer having versatile nature because of its two chlorine atoms attached on both sides of phosphorus atom of its polymeric backbone, it can be easily replaced by nucleophilic substitution reaction. A plenty of work has been explored for its biomedical applications such as tissue engineering, vaccine drug delivery, polyphosphazene- anticancer drug conjugates with doxorubicin, paclitaxel, platinum complexes, methotrexate and gemcitabine for the targeted drug delivery etc. This review is focused on the recent advances in the biomedical applications of polyphosphazene-drug conjugates.
Keywords: Polymer drug conjugates, polyphosphazene, methotrexate, polymeric backbone.
Mini-Reviews in Medicinal Chemistry
Title:Recent Advances in Polymer Drug Conjugates
Volume: 15 Issue: 9
Author(s): Rajiv Sharma, Nishu Singla, Sahil Mehta, Tripti Gaba, Ravinder K. Rawal, H.S. Rao and T.R. Bhardwaj
Affiliation:
Keywords: Polymer drug conjugates, polyphosphazene, methotrexate, polymeric backbone.
Abstract: Polymer drug conjugates play an important role in the delivery of drugs. In the polymeric drug conjugates, the bioactive agent is combined covalently with polymer to achieve the efficient delivery of bioactive agents in the required or specific period of time along with the enhancement of permeability and retention time. A large number of biodegradable polymers have been widely used in the area of biomedical science. Among them, polyphosphazene, is a biodegradable polymer having versatile nature because of its two chlorine atoms attached on both sides of phosphorus atom of its polymeric backbone, it can be easily replaced by nucleophilic substitution reaction. A plenty of work has been explored for its biomedical applications such as tissue engineering, vaccine drug delivery, polyphosphazene- anticancer drug conjugates with doxorubicin, paclitaxel, platinum complexes, methotrexate and gemcitabine for the targeted drug delivery etc. This review is focused on the recent advances in the biomedical applications of polyphosphazene-drug conjugates.
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Sharma Rajiv, Singla Nishu, Mehta Sahil, Gaba Tripti, Rawal K. Ravinder, Rao H.S. and Bhardwaj T.R., Recent Advances in Polymer Drug Conjugates, Mini-Reviews in Medicinal Chemistry 2015; 15 (9) . https://dx.doi.org/10.2174/1389557515666150519104507
DOI https://dx.doi.org/10.2174/1389557515666150519104507 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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