Regulation of Meiosis Initiation before the Commitment Point in Budding Yeast: A Review of Biology, Molecular Mechanisms and Related Mathematical Models
Champi T. Wannige,
We present a review of the initiation of meiosis in budding yeast, Saccharomyces
cerevisiae, specially focusing on the initiation stage before the commitment point. We discuss the
molecular mechanisms involved in tight regulation of the initiation process using experimental facts
and present a comprehensive discussion of the advantages and limitations of the available
mathematical models on the meiosis initiation of budding yeast. We also succinctly review the biology
of general meiosis initiation and the morphology of the modelling organism Saccharomyces cerevisiae
which are helpful to understand the molecular mechanisms involved in context. While explaining the
key molecular mechanisms, the available experimental literature and mathematical models open up emerging questions
for future investigations. Although the complete molecular network and mechanisms of the meiosis initiation in budding
yeast, which can be considered as the best understood meiosis modelling organism, are still not known, the current
explanations can be beneficial for understanding key issues of the meiosis in multicellular organisms.
Keywords: Budding yeast, mitosis, mathematical models, nutrient dependence, Sporulation, Saccharomyces cerevisiae.
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