Group I metabotropic glutamate receptors mediate slow excitatory neurotransmission in the
central nervous system and are critical to activity-dependent synaptic plasticity, a cellular substrate of
learning and memory. Dysregulated receptor signaling is implicated in neuropsychiatric conditions
ranging from neurodevelopmental to neurodegenerative disorders. Importantly, group I metabotropic
glutamate receptor signaling functions can be modulated by interacting proteins that mediate receptor
trafficking, expression and coupling efficiency to signaling effectors. These interactions afford cell- or
pathway-specific modulation to fine-tune receptor function, thus representing a potential target for
pharmacological interventions in pathological conditions.
Keywords: Amyloid-β, CaMKIIα, caveolin-1, homer, mGluR, norbin, PrPc, synaptic plasticity.
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