Biological Function and Medicinal Research Significance of G-Quadruplex Interactive Proteins

Author(s): Jun Qiu , Mingxue Wang , Yan Zhang , Ping Zeng , Tian-Miao Ou , Jia-Heng Tan , Shi-Liang Huang , Lin-Kun An , Honggen Wang , Lian-Quan Gu , Zhi-Shu Huang , Ding Li .

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 19 , 2015

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Abstract:

G-quadruplexes are four-stranded DNA structures formed from G-rich sequences that are built around tetrads of hydrogen-bonded guanine bases. Accumulating studies have revealed that Gquadruplex structures are formed in vivo and play important roles in biological processes such as DNA replication, transcription, recombination, epigenetic regulation, meiosis, antigenic variation, and maintenance of telomeres stability. Mounting evidence indicates that a variety of proteins are capable of binding selectively and tightly to G-quadruplex and play essential roles in G-quadruplex-mediated regulation processes. Some of these proteins promote the formation or/and stabilization of Gquadruplex, while some other proteins act to unwind G-quadruplex preferentially. From a drug discovery perspective, many of these G-quadruplex binding proteins and/or their complexes with G-quadruplexes are potential drug targets. Here, we present a general summary of reported G-quadruplex binding proteins and their biological functions, with focus on those of medicinal research significance. We elaborated the possibility for some of these G-quadruplex binding proteins and their complexes with G-quadruplexes as potential drug targets.

Keywords: Drug targets, G-quadruplex, G-quadruplex interactive protein, DNA, RNA.

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Article Details

VOLUME: 15
ISSUE: 19
Year: 2015
Page: [1971 - 1987]
Pages: 17
DOI: 10.2174/1568026615666150515150803
Price: $58

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