RNA G-Quadruplex: The New Potential Targets for Therapy

Author(s): Shi-Ke Wang, Yue Wu, Tian-Miao Ou.

Journal Name: Current Topics in Medicinal Chemistry

Volume 15 , Issue 19 , 2015

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Abstract:

Roles of RNA on transcriptional and post-transcriptional regulations have raised more attention since the new era of genomics. One of the secondary structures of RNA, the RNA Gquadruplex structure, is demonstrated a relatively stable existence in human tumor cells, virus, or other species relating to diseases. G-quadruplexes are special secondary structures formed by G-rich DNA and RNA sequences that fold into a four-stranded conformation. The G-quadruplexes formed in RNA are involved in many biological process including telomere elongation, transcription regulate, pre-mRNA splicing and translation. In this review, we will give a brief introduction to the structures of RNA G-quadruplexes, the biological roles and the potential to be as drug targets.

Keywords: G-quadruplex, RNA, Drug targets, Biological function, DNA.

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Article Details

VOLUME: 15
ISSUE: 19
Year: 2015
Page: [1947 - 1956]
Pages: 10
DOI: 10.2174/1568026615666150515145733
Price: $58

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