Calcium channel blockers (CCBs) are a heterogeneous group of drugs often used in the
therapy for hypertension and angina. Though CCBs are generally similar in terms of their efficacy yet,
they differ in their ability of causing selective inhibition in the contractility of vascular smooth muscle
in comparison to cardiac muscle. Felodipine is one of the most vascular selective of the available
CCBs and it has no negative inotropic effects at clinically administered doses. Focus of this review is
to comprehensively summarize the pharmacokinetics, efficacy, safety and tolerability of felodipine.
This review is based on evaluation of relevant literature on felodipine using meta-database PubMed
and ScienceDirect and internet search engine (Google Scholar). Clinical studies summarized in this review testify, on
technical lines, the clinical efficacy, safety and placebo- like tolerability profile of felodipine, administered alone as well
as in combination.