Inflammation Fuels Tumor Progress and Metastasis

Author(s): Jingyi Liu , Pengnian Charles Lin , Binhua P. Zhou .

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 21 , 2015

Abstract:

Inflammation is a beneficial response that can remove pathogens, repair injured tissue and restore homeostasis to damaged tissues and organs. However, increasing evidence indicate that chronic inflammation plays a pivotal role in tumor development, as well as progression, metastasis, and resistance to chemotherapy. We will review the current knowledge regarding the contribution of inflammation to epithelial mesenchymal transition. We will also provide some perspectives on the relationship between ER-stress signals and metabolism, and the role of these processes in the development of inflammation.

Keywords: Epithelial-mesenchymal transition, inflammation, metastasis.

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Article Details

VOLUME: 21
ISSUE: 21
Year: 2015
Page: [3032 - 3040]
Pages: 9
DOI: 10.2174/1381612821666150514105741
Price: $58

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