PPARδ Signaling Regulates Colorectal Cancer

Author(s): Mengli You, Shuping Yuan, Juanjuan Shi, Yongzhong Hou.

Journal Name: Current Pharmaceutical Design

Volume 21 , Issue 21 , 2015

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Abstract:

Peroxisome proliferator-activated receptorδ (PPARδ) belongs to the PPARs receptor family including PPARα, PPARδ, and PPARγ. PPARδ is a ligand-activated transcription factor that plays a critical role in regulating cancer progression. PPARδ-linked tumorigenesis was first identified in colorectal cancer, which is demonstrated by the following evidences, so PPARε is a potential drug target for colorectal cancer. In contrast, some observations show that PPARδ negatively regulates colorectal cancer event. In the present review, the recent progress of PPARδ signaling-mediated colorectal cancer is covered.

Keywords: Colorectal cancer, PPARδ, signaling.

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Article Details

VOLUME: 21
ISSUE: 21
Year: 2015
Page: [2956 - 2959]
Pages: 4
DOI: 10.2174/1381612821666150514104035
Price: $58

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