Abstract
Peroxisome proliferator-activated receptorδ (PPARδ) belongs to the PPARs receptor family including PPARα, PPARδ, and PPARγ. PPARδ is a ligand-activated transcription factor that plays a critical role in regulating cancer progression. PPARδ-linked tumorigenesis was first identified in colorectal cancer, which is demonstrated by the following evidences, so PPARε is a potential drug target for colorectal cancer. In contrast, some observations show that PPARδ negatively regulates colorectal cancer event. In the present review, the recent progress of PPARδ signaling-mediated colorectal cancer is covered.
Keywords: Colorectal cancer, PPARδ, signaling.
Current Pharmaceutical Design
Title:PPARδ Signaling Regulates Colorectal Cancer
Volume: 21 Issue: 21
Author(s): Mengli You, Shuping Yuan, Juanjuan Shi and Yongzhong Hou
Affiliation:
Keywords: Colorectal cancer, PPARδ, signaling.
Abstract: Peroxisome proliferator-activated receptorδ (PPARδ) belongs to the PPARs receptor family including PPARα, PPARδ, and PPARγ. PPARδ is a ligand-activated transcription factor that plays a critical role in regulating cancer progression. PPARδ-linked tumorigenesis was first identified in colorectal cancer, which is demonstrated by the following evidences, so PPARε is a potential drug target for colorectal cancer. In contrast, some observations show that PPARδ negatively regulates colorectal cancer event. In the present review, the recent progress of PPARδ signaling-mediated colorectal cancer is covered.
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Cite this article as:
You Mengli, Yuan Shuping, Shi Juanjuan and Hou Yongzhong, PPARδ Signaling Regulates Colorectal Cancer, Current Pharmaceutical Design 2015; 21 (21) . https://dx.doi.org/10.2174/1381612821666150514104035
DOI https://dx.doi.org/10.2174/1381612821666150514104035 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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