Synthesis of Daumone Derivatives and their Antiangiogenic Activities on Chorioallantoic Membrane

Author(s): Jeremy Ricci, Dongguk Min, Miyeon Oh, Hyenchong Lim, Won-Yoon Chung, Kwang-Kyun Park, Mankil Jung.

Journal Name: Medicinal Chemistry

Volume 11 , Issue 8 , 2015

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Abstract:

Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13 showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide, replacing these as the most potent known antiangiogenic agents.

Keywords: Daumone, glycolipid, antiangiogenic activity, synthesis.

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Article Details

VOLUME: 11
ISSUE: 8
Year: 2015
Page: [747 - 752]
Pages: 6
DOI: 10.2174/1573406411666150514100630
Price: $58

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