Daumone, a dauer-inducing pheromone and a series of lipid derivatives were synthesized
from daumone to investigate structure-activity trends. Lipid derivatives demonstrated potent in vivo
antiangiogenic activity on the chorioallantoic membrane, which exceeded that of fumagillin and thalidomide
as reference agents. Among the 11 synthetic compounds tested, new derivatives 3, 11 and 13
showed the most potent antiangiogenic activity, which was twice that of fumagillin and thalidomide,
replacing these as the most potent known antiangiogenic agents.
Keywords: Daumone, glycolipid, antiangiogenic activity, synthesis.
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