The synthesis of high optical purity chiral compounds is of current importance in organic and organometallic
areas of the chemistry with further boost. Chiral compounds are important because of wide use in
many areas such as pharmacy and food industry, etc. Reagents, catalysts or chiral auxiliaries that can control the
stereochemistry of the products are required for the synthesis of chiral compounds. Furthermore, the reagents used
must be able to be recycled. In recent decades, Ephedra derivative compounds have been widely used as catalyst
chiral ligands or chiral inductors in asymmetric synthesis. To our knowledge, no review about Ephedra derivative
compounds as chiral auxiliaries used with organometallics in alkylation reactions to carbonyl compounds, has been published. In this paper,
the use of N-substituted and N-disubstituted ephedra compounds as chiral auxiliary ligands in alkylation, alkenylation and alquinilation
reactions of carbonyl and imine compounds is summarized.
Keywords: Chiral auxiliaries, Asymmetric synthesis, Enantioselectivity, Ephedrines, Organometallics.
Rights & PermissionsPrintExport