Involvement of CYP 3A5 In the Interaction Between Tacrolimus and Nicardipine: A Case Report

Author(s): Mouna B. Sassi , Emna Gaies , Issam Salouage , Sameh Trabelsi , Mohamed Lakhal , Anis Klouz .

Journal Name: Current Drug Safety

Volume 10 , Issue 3 , 2015

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Abstract:

Tacrolimus is a calcineurin inhibitor primarily metabolized by CYP3A4 and secondarily by CYP3A5. Several drugs can modify tacrolimus blood levels as calcium channel blockers (CCBs). Interaction with nicardipine was reported in some cases.

A man with a history of malignant arterial hypertension treated with nicardipine, underwent kidney transplantation. After transplantation, he was treated with tacrolimus, mycophenolate mofetil and corticoids. Therapeutic drug monitoring of tacrolimus was done regularly showing a mean trough concentration (C0) of 24.39 ng/mL with some concentrations reaching 52 ng/mL. After changing nicardipine by prazosine, the first tacrolimus C0 after stopping nicardipine was 3.2 ng/mL.

Increase of tacrolimus trough concentrations is due to the inhibition of CYP3A4. Very high levels of tacrolimus suggest the non expression of CYP3A5. Thus, because of the possible lack of the secondary pathway, therapeutic drug monitoring of tacrolimus is highly recommended at the introduction of CCBs and also at its stopping.

Keywords: CYP 3A5, drug interaction, nicardipine, renal transplantation, tacrolimus, therapeutic drug monitoring.

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Article Details

VOLUME: 10
ISSUE: 3
Year: 2015
Page: [254 - 256]
Pages: 3
DOI: 10.2174/1574886310666150512105459
Price: $58

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